What is dUMP and dTMP?
Deoxyuridine suppression test The conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) during DNA synthesis is by methyl group transfer, facilitated by both vitamin B12 and folate.
Which anticancer drug inhibits the thymidylate synthase?
5-Fluorouracil is a prototypic drug known to inhibit thymidylate synthase. However, thymidylate synthase has also been proposed as a target for pemetrexed, which has become a cornerstone drug for patients with nonsquamous NSCLC.
Why is thymidylate synthase important?
Thymidylate synthase plays a central role in the biosynthesis of thymidylate, an essential precursor for DNA biosynthesis. In addition to its role in catalysis and cellular metabolism, studies from our laboratory have shown that thymidylate synthase functions as an RNA binding protein.
How is thymidylate derived?
Thymidylate Is Derived from dCDP and dUMP In bacteria, the pathway to dUMP begins with formation of dUTP, either by deamination of dCTP or by phosphorylation of dUDP (Fig. 21-36). The dUTP is converted to dUMP by a dUTPase. The conversion of dUMP to dTMP is catalyzed by the enzyme thymidylate synthase.
What does dTMP mean?
Thymidine monophosphate (TMP), also known as thymidylic acid (conjugate base thymidylate), deoxythymidine monophosphate (dTMP), or deoxythymidylic acid (conjugate base deoxythymidylate), is a nucleotide that is used as a monomer in DNA.
What is dTMP used for?
Thymidylate (dTMP) is a key metabolite required for the accurate replication of DNA genomes in all cellular organisms. De novo synthesis of dTMP requires thymidylate synthase that methylates dUMP.
Which of the following drugs inhibit thymidylate synthase?
Thymidylate synthase inhibitors including 5-FU, capecitabine, and raltitrexed have been tested in the clinic in combination with gemcitabine.
Which is a potent inhibitor of thymidylate synthase?
The antipyrimidine drug, 5-fluorouracil (5-FU), as its active metabolite, FdUMP, is a potent inhibitor of thymidylate synthase (TS), and this is generally considered to be its primary mechanism of action (Pratt et al., 1994).
Why is thymidylate synthase important for converting dUMP to dTMP?
Thymidylate synthase (TS) catalyzes the conversion of dUMP to dTMP, a rate-limiting step in DNA synthesis. Inhibition of TS results in depletion of cellular nucleotide pools [85]. Further, the inhibition of TS activates hENT1 and increases antitumor response of GEM therapy [86].
What is the thymidylate synthase gene?
TYMS (Thymidylate Synthetase) is a Protein Coding gene. Diseases associated with TYMS include Mucositis and Rectum Cancer. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Metabolism of nucleotides.
How is thymidine synthesized?
Synthesis of Thymidine Nucleotides De novo synthesis of thymidylic acid (TMP) occurs exclusively by methylation of the C-5 of dUMP (Figure 25.18) by thymidylate synthase. Fluorodeoxyuridylate inhibits conversion of dUMP to TMP, and methotrexate inhibits regeneration of the tetrahydrofolate coenzyme.
What does DTMF mean in slang?
| DTMF | Dual-Tone Multi-Frequency Governmental » Military — and more… |
|---|---|
| DTMF | Dump The Mother Figure Internet » Chat |
| DTMF | Dual Tone Multi Frequency Miscellaneous » Unclassified — and more… |
| DTMF | Dual Tone Mutli Frequency Miscellaneous » Unclassified |
| DTMF | Dual Tone Multiple Frequency Miscellaneous » Unclassified |